Compound Detail
CHEMBL5177846
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Basic Information
| ChEMBL ID | CHEMBL5177846 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AHDQPITWFVUJKR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
489.5
MW (Da)
2.31
ALogP
7
HBA
1
HBD
107.1
PSA (Ų)
0.68
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 10.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Orexin receptor type 2 CHEMBL4792 | IC50 | 10.15 | 10.15 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Orexin receptor type 2 | IC50 | = | 0.07 | nM | 10.15 | Agonist activity at human OX2R expressed in CHO cells incubated for 2 hrs by IP-... | 36105324 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36105324 | 10.1021/acsmedchemlett.2c00341 | Orexin receptor type 2 | 1 |
Data from ChEMBL 36 via Core Engine