Assay Detail

CHEMBL5150179

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Binding

Inhibition of HRAS (unknown origin) farnesylation

ChEMBL ↗

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Target

GTPase HRas (CHEMBL2167) ↗

Open DB target context

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GTPase HRas (CHEMBL2167) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target GTPase HRas

CHEMBL2167

Anchored from Assay target.

Protein identity GTPase HRas

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

GTPase HRas (CHEMBL2167) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway.

Korzeniecki C, Priefer R.
Eur J Med Chem (2021) 211 : 113006 -113006
PubMed 33228976 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC90	1	-	-
IC50	1	8.89	8.89

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL351706	BMS-214662	1.0	2	8.89

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL351706	BMS-214662	IC50	=	1.3	nM	8.89
CHEMBL351706	BMS-214662	IC90	=	18.0	nM	-