Assay Detail
Binding
CHEMBL5150283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK3 (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.96 | 9.15 |
| Ki | 1 | 9.70 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 9.70 |
| CHEMBL3137308 | PEFICITINIB | 4.0 | 1 | 9.15 |
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3137308 | PEFICITINIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1287853 | FEDRATINIB | IC50 | = | 169.0 | nM | 6.77 |