Assay Detail
Binding
CHEMBL5150284
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 (unknown origin)
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 8.36 | 8.36 |
| IC50 | 1 | 8.32 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 8.36 |
| CHEMBL3137308 | PEFICITINIB | 4.0 | 1 | 8.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL3137308 | PEFICITINIB | IC50 | = | 4.8 | nM | 8.32 |