Assay Detail
Binding
CHEMBL5150417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR DEL19 mutant in human HCC827 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.04 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786343 | OLMUTINIB | 4.0 | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786343 | OLMUTINIB | IC50 | = | 9.2 | nM | 8.04 |