Assay Detail
Functional
CHEMBL5151052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human RKO cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RKO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.66 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | 3.0 | 1 | 6.78 |
| CHEMBL5177755 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL5177755 | — | IC50 | = | 286.0 | nM | 6.54 |