Assay Detail
Functional
CHEMBL5151310
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Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.67 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182623 | — | — | 1 | 10.40 |
| CHEMBL5192239 | — | — | 1 | 10.14 |
| CHEMBL2103835 | — | — | 1 | 10.02 |
| CHEMBL5206108 | — | — | 1 | 9.89 |
| CHEMBL5208408 | — | — | 1 | 9.64 |
| CHEMBL3326882 | — | — | 1 | 9.49 |
| CHEMBL5200776 | — | — | 1 | 9.44 |
| CHEMBL5171810 | — | — | 1 | 9.42 |
| CHEMBL5170544 | — | — | 1 | 9.31 |
| CHEMBL5183877 | — | — | 1 | 9.30 |
| CHEMBL5192042 | — | — | 1 | 9.26 |
| CHEMBL5200172 | — | — | 1 | 9.22 |
| CHEMBL5181782 | — | — | 1 | 9.20 |
| CHEMBL5186863 | — | — | 1 | 9.19 |
| CHEMBL5194640 | — | — | 1 | 9.09 |
| CHEMBL5176627 | — | — | 1 | 8.97 |
| CHEMBL5181118 | — | — | 1 | 8.97 |
| CHEMBL5198044 | — | — | 1 | 8.86 |
| CHEMBL5179078 | — | — | 1 | 8.75 |
| CHEMBL5189338 | — | — | 1 | 8.71 |
| CHEMBL5199708 | — | — | 1 | 8.67 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.61 |
| CHEMBL5185510 | — | — | 1 | 8.54 |
| CHEMBL5169880 | — | — | 1 | 8.54 |
| CHEMBL5184158 | — | — | 1 | 8.53 |
| CHEMBL5191718 | — | — | 1 | 8.50 |
| CHEMBL5201280 | — | — | 1 | 8.43 |
| CHEMBL5198941 | — | — | 1 | 8.34 |
| CHEMBL5206472 | — | — | 1 | 8.21 |
| CHEMBL5176052 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182623 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5192239 | — | IC50 | = | 0.072 | nM | 10.14 |
| CHEMBL2103835 | — | IC50 | = | 0.096 | nM | 10.02 |
| CHEMBL5206108 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL5208408 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL3326882 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL5200776 | — | IC50 | = | 0.364 | nM | 9.44 |
| CHEMBL5171810 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL5170544 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL5183877 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5192042 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL5200172 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5181782 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL5186863 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL5194640 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL5176627 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL5181118 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL5198044 | — | IC50 | = | 1.37 | nM | 8.86 |
| CHEMBL5179078 | — | IC50 | = | 1.76 | nM | 8.75 |
| CHEMBL5189338 | — | IC50 | = | 1.97 | nM | 8.71 |
| CHEMBL5199708 | — | IC50 | = | 2.15 | nM | 8.67 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.47 | nM | 8.61 |
| CHEMBL5185510 | — | IC50 | = | 2.87 | nM | 8.54 |
| CHEMBL5169880 | — | IC50 | = | 2.87 | nM | 8.54 |
| CHEMBL5184158 | — | IC50 | = | 2.96 | nM | 8.53 |
| CHEMBL5191718 | — | IC50 | = | 3.19 | nM | 8.50 |
| CHEMBL5201280 | — | IC50 | = | 3.71 | nM | 8.43 |
| CHEMBL5198941 | — | IC50 | = | 4.58 | nM | 8.34 |
| CHEMBL5176052 | — | IC50 | = | 6.16 | nM | 8.21 |
| CHEMBL5206472 | — | IC50 | = | 6.16 | nM | 8.21 |
| CHEMBL5193826 | — | IC50 | = | 11.26 | nM | 7.95 |
| CHEMBL5185652 | — | IC50 | = | 14.94 | nM | 7.83 |
| CHEMBL5193399 | — | IC50 | = | 76.66 | nM | 7.12 |
| CHEMBL2331577 | THAILANSTATIN C | IC50 | = | 136.7 | nM | 6.86 |
| CHEMBL5196008 | — | IC50 | = | 264.5 | nM | 6.58 |
| CHEMBL2333561 | THAILANSTATIN A | IC50 | = | 418.6 | nM | 6.38 |
| CHEMBL2333560 | THAILANSTATIN B | IC50 | = | 856.3 | nM | 6.07 |
| CHEMBL3326877 | — | IC50 | > | 1000.0 | nM | - |