Assay Detail
Binding
CHEMBL5151674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His6-tagged human NIK (330 to 680 residues) S549D mutant expressed in baculovirus-infected Sf9 cells incubated for 30 mins in presence of ATP by ADP-GloTM assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 14 (CHEMBL5888) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.47 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3187788 | — | — | 1 | 8.40 |
| CHEMBL4211840 | — | — | 1 | 8.00 |
| CHEMBL2334589 | — | — | 1 | 7.40 |
| CHEMBL5196202 | — | — | 1 | 6.70 |
| CHEMBL5198459 | — | — | 1 | 6.60 |
| CHEMBL5175837 | — | — | 1 | 6.50 |
| CHEMBL5170825 | — | — | 1 | 5.80 |
| CHEMBL5182375 | — | — | 1 | 5.80 |
| CHEMBL5196977 | — | — | 1 | 5.80 |
| CHEMBL5197109 | — | — | 1 | 5.50 |
| CHEMBL5206628 | — | — | 1 | 5.20 |
| CHEMBL5198316 | — | — | 1 | 5.20 |
| CHEMBL5185097 | — | — | 1 | 4.70 |
| CHEMBL5175595 | — | — | 1 | 4.60 |
| CHEMBL5182501 | — | — | 1 | 4.50 |
| CHEMBL5203009 | — | — | 1 | 4.40 |
| CHEMBL5181977 | — | — | 1 | 4.40 |
| CHEMBL5194484 | — | — | 1 | 4.30 |
| CHEMBL5182228 | — | — | 1 | 4.20 |
| CHEMBL5190943 | — | — | 1 | 4.10 |
| CHEMBL5190105 | — | — | 1 | 4.10 |
| CHEMBL5175142 | — | — | 1 | 4.10 |
| CHEMBL5204146 | — | — | 1 | - |
| CHEMBL5192481 | — | — | 1 | - |
| CHEMBL5190680 | — | — | 1 | - |
| CHEMBL5203081 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3187788 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4211840 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2334589 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5196202 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5198459 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5175837 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL5170825 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL5182375 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL5196977 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL5197109 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL5206628 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL5198316 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL5185097 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL5175595 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL5182501 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL5203009 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL5181977 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL5194484 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL5182228 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL5190943 | — | IC50 | = | 79432.82 | nM | 4.10 |
| CHEMBL5190105 | — | IC50 | = | 79432.82 | nM | 4.10 |
| CHEMBL5175142 | — | IC50 | = | 79432.82 | nM | 4.10 |
| CHEMBL5204146 | — | IC50 | = | 501187.23 | nM | - |
| CHEMBL5192481 | — | IC50 | = | 501187.23 | nM | - |
| CHEMBL5190680 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5203081 | — | IC50 | = | 398107.17 | nM | - |