Assay Detail

CHEMBL5151769

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Toxicity

Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter assay

ChEMBL ↗

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Target

BHK-21 (CHEMBL614527) ↗

Open DB target context

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BHK-21 (CHEMBL614527) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target BHK-21

CHEMBL614527

Anchored from Assay target.

Protein identity BHK-21

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Toxicity
Organism	Mesocricetus auratus
Cell Type	BHK-21
Confidence	1 — Organism
Curated By	Autocuration

Target

BHK-21 (CHEMBL614527) ↗

Type	CELL-LINE
Organism	Mesocricetus auratus

Publication

Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors.

Nascimento IJDS, Santos-Júnior PFDS, Aquino TM, Araújo-Júnior JX, Silva-Júnior EFD.
Eur J Med Chem (2021) 224 : 113698 -113698
PubMed 34274831 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.12	6.12

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL220745	PODOCARPUSFLAVONE A	—	1	6.12

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL220745	PODOCARPUSFLAVONE A	IC50	=	750.0	nM	6.12