Assay Detail
Binding
CHEMBL5151770
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Inhibition of DENV NS5/RNA-dependent RNA polymerase
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Dengue virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.46 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450522 | SOTETSUFLAVONE | — | 1 | 6.80 |
| CHEMBL220745 | PODOCARPUSFLAVONE A | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450522 | SOTETSUFLAVONE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL220745 | PODOCARPUSFLAVONE A | IC50 | = | 750.0 | nM | 6.12 |