Assay Detail
Binding
CHEMBL5152496
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Inhibition of recombinant human GSTA1-1 using GSH and CDNB as substrate preincubated for 5 mins followed by substrate addition and measured in the absence of UV irradiation by spectrophotometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of glutathione S-transferases by photoactive calix[4]arene α-ketophosphonic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.69 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178537 | — | — | 1 | 6.80 |
| CHEMBL5169380 | — | — | 1 | 6.55 |
| CHEMBL5203780 | — | — | 1 | 5.54 |
| CHEMBL5184218 | — | — | 1 | 5.28 |
| CHEMBL5199600 | — | — | 1 | 4.98 |
| CHEMBL5174343 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178537 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5169380 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5203780 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL5184218 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5199600 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL5174343 | — | IC50 | = | 10510.0 | nM | 4.98 |