Assay Detail
Binding
CHEMBL5152875
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Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hrs by Rapidfire mass spectrometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Photoredox-based late-stage functionalization in SAR study for in vivo potent glucosylceramide synthase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.86 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5181454 | — | — | 1 | 8.44 |
| CHEMBL5197585 | — | — | 1 | 8.37 |
| CHEMBL5178033 | — | — | 1 | 8.23 |
| CHEMBL5193757 | — | — | 1 | 8.13 |
| CHEMBL5198393 | — | — | 1 | 8.04 |
| CHEMBL5185934 | — | — | 1 | 8.00 |
| CHEMBL5182659 | — | — | 1 | 7.96 |
| CHEMBL5183525 | — | — | 1 | 7.89 |
| CHEMBL5186203 | — | — | 1 | 7.80 |
| CHEMBL5185095 | — | — | 1 | 7.80 |
| CHEMBL5186505 | — | — | 1 | 7.66 |
| CHEMBL5200972 | — | — | 1 | 7.28 |
| CHEMBL5192371 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5181454 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5197585 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL5178033 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5193757 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5198393 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5185934 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5182659 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5183525 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5186203 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5185095 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5186505 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5200972 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5192371 | — | IC50 | = | 250.0 | nM | 6.60 |