Assay Detail
Functional
CHEMBL5152979
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Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 4.79 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177265 | — | — | 1 | 5.75 |
| CHEMBL5178695 | — | — | 1 | 5.60 |
| CHEMBL3115912 | — | — | 1 | 5.39 |
| CHEMBL3115914 | — | — | 1 | 5.21 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.96 |
| CHEMBL187926 | — | — | 1 | 4.96 |
| CHEMBL5170692 | — | — | 1 | 4.80 |
| CHEMBL34398 | 4'-METHOXYCHALCONE | — | 1 | 4.77 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | — | 1 | 4.68 |
| CHEMBL463017 | — | — | 1 | 4.64 |
| CHEMBL1927391 | — | — | 1 | 4.62 |
| CHEMBL5209316 | — | — | 1 | 4.60 |
| CHEMBL5202538 | — | — | 1 | 4.55 |
| CHEMBL105496 | 4-METHOXY CHALCONE | — | 1 | 4.52 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | — | 1 | 4.50 |
| CHEMBL3115924 | — | — | 1 | 4.35 |
| CHEMBL5185585 | — | — | 1 | 4.23 |
| CHEMBL1578953 | — | — | 1 | 4.14 |
| CHEMBL207313 | — | — | 1 | - |
| CHEMBL5185073 | — | — | 1 | - |
| CHEMBL490512 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177265 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5178695 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3115912 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3115914 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL7976 | CHALCONE | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL187926 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5170692 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL34398 | 4'-METHOXYCHALCONE | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL463017 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1927391 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5209316 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5202538 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL105496 | 4-METHOXY CHALCONE | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3115924 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL5185585 | — | EC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL1578953 | — | EC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL207313 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5185073 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL490512 | — | EC50 | > | 100000.0 | nM | - |