Assay Detail
Functional
CHEMBL5153641
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.51 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179871 | — | — | 1 | 7.22 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.31 |
| CHEMBL5177696 | — | — | 1 | 6.09 |
| CHEMBL5181688 | — | — | 1 | 5.87 |
| CHEMBL5198510 | — | — | 1 | 5.85 |
| CHEMBL5173348 | — | — | 1 | 5.82 |
| CHEMBL5170945 | — | — | 1 | 5.77 |
| CHEMBL5178408 | — | — | 1 | 5.71 |
| CHEMBL5170820 | — | — | 1 | 5.66 |
| CHEMBL5206740 | — | — | 1 | 5.65 |
| CHEMBL5191744 | — | — | 1 | 5.65 |
| CHEMBL5199914 | — | — | 1 | 5.53 |
| CHEMBL3545376 | ERDAFITINIB | 4.0 | 1 | 5.37 |
| CHEMBL5186714 | — | — | 1 | 5.34 |
| CHEMBL5170264 | — | — | 1 | 5.28 |
| CHEMBL5202576 | — | — | 1 | 5.20 |
| CHEMBL5182360 | — | — | 1 | 5.12 |
| CHEMBL5203230 | — | — | 1 | 5.12 |
| CHEMBL5204809 | — | — | 1 | 5.03 |
| CHEMBL5186645 | — | — | 1 | 5.02 |
| CHEMBL5187998 | — | — | 1 | 4.97 |
| CHEMBL5179314 | — | — | 1 | 4.93 |
| CHEMBL5202912 | — | — | 1 | 4.92 |
| CHEMBL5183668 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179871 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5177696 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5181688 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL5198510 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL5173348 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL5170945 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL5178408 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5170820 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5206740 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL5191744 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL5199914 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL3545376 | ERDAFITINIB | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL5186714 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL5170264 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL5202576 | — | IC50 | = | 6370.0 | nM | 5.20 |
| CHEMBL5182360 | — | IC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL5203230 | — | IC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL5204809 | — | IC50 | = | 9320.0 | nM | 5.03 |
| CHEMBL5186645 | — | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL5187998 | — | IC50 | = | 10750.0 | nM | 4.97 |
| CHEMBL5179314 | — | IC50 | = | 11680.0 | nM | 4.93 |
| CHEMBL5202912 | — | IC50 | = | 12130.0 | nM | 4.92 |
| CHEMBL5183668 | — | IC50 | = | 14880.0 | nM | 4.83 |