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Assay Detail

CHEMBL5153642

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Functional
Antiproliferative activity against human SNU-16 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SNU-16
Confidence 1 — Organism
Curated By Autocuration

Target

SNU-16 (CHEMBL613529)
Type CELL-LINE
Organism Homo sapiens

Publication

Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer.
Wan G, Feng Z, Zhang Q, Li X, Ran K, Feng H, Luo T, Zhou S, Su C, Wei W, Wang N, Gao C, Zhao L, Yu L.
J Med Chem (2022) 65 : 16541 -16569
PubMed 36449947 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 7.66 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5177696 1 9.15
CHEMBL3545376 ERDAFITINIB 4.0 1 9.15
CHEMBL5186645 1 8.85
CHEMBL5181688 1 8.54
CHEMBL5178408 1 8.43
CHEMBL5170945 1 8.19
CHEMBL5186714 1 8.15
CHEMBL5198510 1 8.00
CHEMBL5202576 1 8.00
CHEMBL5182360 1 7.70
CHEMBL5187998 1 7.70
CHEMBL5203230 1 7.52
CHEMBL5170264 1 7.52
CHEMBL5191744 1 7.40
CHEMBL5179871 1 7.30
CHEMBL5202912 1 7.10
CHEMBL5179314 1 6.92
CHEMBL5183668 1 6.82
CHEMBL5204809 1 6.58
CHEMBL5199914 1 6.57
CHEMBL98 VORINOSTAT 4.0 1 6.54
CHEMBL5170820 1 6.37
CHEMBL5206740 1 -
CHEMBL5173348 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5177696 IC50 = 0.7 nM 9.15
CHEMBL3545376 ERDAFITINIB IC50 = 0.7 nM 9.15
CHEMBL5186645 IC50 = 1.4 nM 8.85
CHEMBL5181688 IC50 = 2.9 nM 8.54
CHEMBL5178408 IC50 = 3.7 nM 8.43
CHEMBL5170945 IC50 = 6.4 nM 8.19
CHEMBL5186714 IC50 = 7.1 nM 8.15
CHEMBL5198510 IC50 = 10.0 nM 8.00
CHEMBL5202576 IC50 = 10.0 nM 8.00
CHEMBL5182360 IC50 = 20.0 nM 7.70
CHEMBL5187998 IC50 = 20.0 nM 7.70
CHEMBL5203230 IC50 = 30.0 nM 7.52
CHEMBL5170264 IC50 = 30.0 nM 7.52
CHEMBL5191744 IC50 = 40.0 nM 7.40
CHEMBL5179871 IC50 = 50.0 nM 7.30
CHEMBL5202912 IC50 = 80.0 nM 7.10
CHEMBL5179314 IC50 = 120.0 nM 6.92
CHEMBL5183668 IC50 = 150.0 nM 6.82
CHEMBL5204809 IC50 = 260.0 nM 6.58
CHEMBL5199914 IC50 = 270.0 nM 6.57
CHEMBL98 VORINOSTAT IC50 = 290.0 nM 6.54
CHEMBL5170820 IC50 = 430.0 nM 6.37
CHEMBL5206740 IC50 < 0.2 nM -
CHEMBL5173348 IC50 < 0.2 nM -