Assay Detail
Functional
CHEMBL5154014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 Ba-L infected in human TZM-bl cells measured after 48 hrs incubation by luciferase based analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.69 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175220 | — | — | 1 | 8.00 |
| CHEMBL5209067 | — | — | 1 | 7.96 |
| CHEMBL256907 | MARAVIROC | 4.0 | 1 | 7.82 |
| CHEMBL5171331 | — | — | 1 | 7.52 |
| CHEMBL4240742 | — | — | 1 | 7.11 |
| CHEMBL5177519 | — | — | 1 | 6.27 |
| CHEMBL5180628 | — | — | 1 | 6.04 |
| CHEMBL5178495 | — | — | 1 | 5.47 |
| CHEMBL5205216 | — | — | 1 | 5.34 |
| CHEMBL5197247 | — | — | 1 | 5.33 |
| CHEMBL5184978 | — | — | 1 | - |
| CHEMBL5205626 | — | — | 1 | - |
| CHEMBL5208613 | — | — | 1 | - |
| CHEMBL5169473 | — | — | 1 | - |
| CHEMBL5194455 | — | — | 1 | - |
| CHEMBL5171807 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175220 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5209067 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL256907 | MARAVIROC | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5171331 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4240742 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5177519 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5180628 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5178495 | — | EC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL5205216 | — | EC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL5197247 | — | EC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL5184978 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL5205626 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5208613 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5169473 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL5194455 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL5171807 | — | EC50 | > | 200000.0 | nM | - |