Assay Detail
Functional
CHEMBL5154031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 KIZ001 clinical isolate infected in human PBMC measured after 48 hrs incubation by luciferase based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.07 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175220 | — | — | 1 | 8.28 |
| CHEMBL5209067 | — | — | 1 | 8.11 |
| CHEMBL256907 | MARAVIROC | 4.0 | 1 | 7.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175220 | — | EC50 | = | 5.26 | nM | 8.28 |
| CHEMBL5209067 | — | EC50 | = | 7.82 | nM | 8.11 |
| CHEMBL256907 | MARAVIROC | EC50 | = | 14.92 | nM | 7.83 |