Assay Detail
Binding
CHEMBL5154109
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium smegmatis MC2 155 recombinant ndhA assessed as rate of NADH oxidation in the presence of an electron acceptor menadione
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycolicibacterium smegmatis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type II NADH:quinone oxidoreductase NdhA (CHEMBL5169229) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.60 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5186518 | — | — | 1 | 7.24 |
| CHEMBL5201484 | — | — | 1 | 7.23 |
| CHEMBL5171834 | — | — | 1 | 7.02 |
| CHEMBL5202255 | — | — | 1 | 6.48 |
| CHEMBL5182198 | — | — | 1 | 6.01 |
| CHEMBL5206556 | — | — | 1 | 5.63 |
| CHEMBL5196810 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5186518 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5201484 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5171834 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL5202255 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5182198 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5206556 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL5196810 | — | IC50 | - | — | - |