Assay Detail
Binding
CHEMBL5154233
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Inhibition of SARS-CoV-2 main protease
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.26 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5173274 | — | — | 1 | 8.10 |
| CHEMBL3427166 | — | — | 1 | 7.52 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5173274 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3427166 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL51085 | EBSELEN | IC50 | = | 670.0 | nM | 6.17 |