Assay Detail
Binding
CHEMBL5154326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV2 main protease
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.79 | 7.40 |
| Ki | 2 | 7.30 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316746 | — | — | 1 | 7.84 |
| CHEMBL4764751 | — | — | 1 | 7.40 |
| CHEMBL5184473 | — | — | 1 | 6.75 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316746 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL4764751 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5184473 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL51085 | EBSELEN | IC50 | = | 670.0 | nM | 6.17 |