Assay Detail
Binding
CHEMBL5154327
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Inhibition of SARS-CoV-2 PLpro
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.49 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197203 | — | — | 1 | 7.03 |
| CHEMBL3983492 | — | — | 1 | 6.59 |
| CHEMBL599894 | — | — | 1 | 6.58 |
| CHEMBL5188743 | — | — | 1 | 6.41 |
| CHEMBL549695 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197203 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3983492 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL599894 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5188743 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL549695 | — | IC50 | = | 1390.0 | nM | 5.86 |