Assay Detail
Binding
CHEMBL5155117
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Inhibition of human cathepsin S incubated for 30 mins by fluorometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.86 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5191060 | — | — | 1 | 7.29 |
| CHEMBL5191092 | — | — | 1 | 6.94 |
| CHEMBL5190213 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5191060 | — | IC50 | = | 51.5 | nM | 7.29 |
| CHEMBL5191092 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL5190213 | — | IC50 | = | 444.0 | nM | 6.35 |