Assay Detail
Binding
CHEMBL5155212
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Binding affinity to wild type TTR/Amyloid beta (1 to 40 residues) binary complex (unknown origin) assessed as complex dissociation constant by isothermal titration calorimetry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.70 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425 | OLSALAZINE | 4.0 | 1 | 6.09 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.82 |
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 5.63 |
| CHEMBL1232738 | — | — | 1 | 5.48 |
| CHEMBL15770 | SULINDAC | 4.0 | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425 | OLSALAZINE | Kd | = | 810.0 | nM | 6.09 |
| CHEMBL151 | LUTEOLIN | Kd | = | 1520.0 | nM | 5.82 |
| CHEMBL23588 | FLUFENAMIC ACID | Kd | = | 2340.0 | nM | 5.63 |
| CHEMBL1232738 | — | Kd | = | 3340.0 | nM | 5.48 |
| CHEMBL15770 | SULINDAC | Kd | = | 3420.0 | nM | 5.47 |