Compound Detail
CHEMBL425
OLSALAZINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL425 |
| Name | OLSALAZINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | QQBDLJCYGRGAKP-FOCLMDBBSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL704 |
2
Targets
4
Activities
2
Assay Types
6
PK Parameters
20
Publications
3
Known Names
1
Indications
Molecular Properties
302.2
MW (Da)
2.91
ALogP
6
HBA
4
HBD
139.8
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1990 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Spondylitis, Ankylosing
ATC Classification
A07EC03
olsalazine
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
Activity Summary
Kd 3 meas. best 7.16
IC50 1 meas. best 5.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Flavin reductase (NADPH) CHEMBL5019 | Kd | 7.16 | 7.155 | 70.0 | 2 |
| Unchecked CHEMBL612545 | Kd | 6.09 | 6.09 | 810.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.02 | 5.02 | 9535.2 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 1.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.9 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.2 | mL.min-1.kg-1 | Homo sapiens |
| F | 2.3 | % | Homo sapiens |
| MRT | 0.97 | hr | Homo sapiens |
| T1/2 | 0.9 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Flavin reductase (NADPH) | Kd | = | 70.0 | nM | 7.16 | Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLV... | 34957824 |
| Flavin reductase (NADPH) | Kd | = | 70.79 | nM | 7.15 | Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLV... | 34957824 |
| Unchecked | Kd | = | 810.0 | nM | 6.09 | Binding affinity to wild type TTR/Amyloid beta (1 to 40 residues) binary complex... | 34555615 |
| Unchecked | IC50 | = | 9535.2 | nM | 5.02 | PubChem BioAssay. GLP1 secretion from STC-1 cells-IC50. (Class of assay: confi... | - |
Literature References
Data from ChEMBL 36 via Core Engine