Assay Detail
Functional
CHEMBL5155240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells expressing wild type EGFR incubated for 72 hrs in absence of cetuximab by Cell Titer-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.33 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098072 | — | — | 1 | 7.70 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 6.96 |
| CHEMBL5188399 | — | — | 1 | - |
| CHEMBL5188250 | — | — | 1 | - |
| CHEMBL5199122 | — | — | 1 | - |
| CHEMBL5183286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098072 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5188399 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5188250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5199122 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5183286 | — | IC50 | > | 10000.0 | nM | - |