Assay Detail
Functional
CHEMBL5155248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells expressing EGFR L858R/T790M mutant incubated for 72 hrs in presence of 1 ug/ml cetuximab by Cell Titer-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.55 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.70 |
| CHEMBL4098072 | — | — | 1 | 8.52 |
| CHEMBL5188399 | — | — | 1 | 5.44 |
| CHEMBL5188250 | — | — | 1 | - |
| CHEMBL5199122 | — | — | 1 | - |
| CHEMBL5183286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4098072 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5188399 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5188250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5199122 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5183286 | — | IC50 | > | 10000.0 | nM | - |