Assay Detail
Binding
CHEMBL5155956
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-2-p-2-(carboxyethyl)phenyl-ethylamino-5'-N-ethylcarboxamidoadenosine from human A2A receptor stably expressed in HEK293 cell membrane by radioligand inhibition assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A<sub>3</sub> adenosine receptor agonists containing dopamine moieties for enhanced interspecies affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.35 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5202349 | — | — | 1 | 6.23 |
| CHEMBL5178814 | — | — | 1 | 5.33 |
| CHEMBL5175945 | — | — | 1 | 5.31 |
| CHEMBL5183720 | — | — | 1 | 5.30 |
| CHEMBL5176856 | — | — | 1 | 5.23 |
| CHEMBL5196916 | — | — | 1 | 5.09 |
| CHEMBL5181821 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5202349 | — | Ki | = | 588.0 | nM | 6.23 |
| CHEMBL5178814 | — | Ki | = | 4720.0 | nM | 5.33 |
| CHEMBL5175945 | — | Ki | = | 4860.0 | nM | 5.31 |
| CHEMBL5183720 | — | Ki | = | 5050.0 | nM | 5.30 |
| CHEMBL5176856 | — | Ki | = | 5860.0 | nM | 5.23 |
| CHEMBL5196916 | — | Ki | = | 8210.0 | nM | 5.09 |
| CHEMBL5181821 | — | Ki | = | 10200.0 | nM | 4.99 |