Assay Detail
Functional
CHEMBL5156609
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Antiproliferative activity against human LNCaP cells assessed as cell growth inhibition by Celltiter-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.45 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4785363 | INOBRODIB | 1.0 | 1 | 7.22 |
| CHEMBL5192803 | — | — | 1 | 6.44 |
| CHEMBL5204688 | — | — | 1 | 6.36 |
| CHEMBL5191045 | — | — | 1 | 6.27 |
| CHEMBL5179520 | — | — | 1 | 6.23 |
| CHEMBL3814752 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4785363 | INOBRODIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5192803 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5204688 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5191045 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5179520 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3814752 | — | IC50 | = | 650.0 | nM | 6.19 |