Assay Detail
Binding
CHEMBL5157022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length wild type LRRK2 (unknown origin) by LRRKtide Adapta assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Leucine-rich repeat serine/threonine-protein kinase 2 (CHEMBL1075104) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 7.23 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098877 | MLi-2 | — | 1 | 9.00 |
| CHEMBL5187271 | — | — | 1 | 8.30 |
| CHEMBL5170359 | — | — | 1 | 8.15 |
| CHEMBL5194735 | — | — | 1 | 8.10 |
| CHEMBL5177346 | — | — | 1 | 8.10 |
| CHEMBL5206337 | — | — | 1 | 8.00 |
| CHEMBL5207998 | — | — | 1 | 7.96 |
| CHEMBL5201248 | — | — | 1 | 7.85 |
| CHEMBL5174552 | — | — | 1 | 7.75 |
| CHEMBL5176421 | — | — | 1 | 7.72 |
| CHEMBL5182067 | — | — | 1 | 7.70 |
| CHEMBL5196967 | — | — | 1 | 7.68 |
| CHEMBL5200822 | — | — | 1 | 7.66 |
| CHEMBL5184816 | — | — | 1 | 7.66 |
| CHEMBL5182980 | — | — | 1 | 7.64 |
| CHEMBL5179734 | — | — | 1 | 7.62 |
| CHEMBL5209350 | — | — | 1 | 7.60 |
| CHEMBL5172598 | — | — | 1 | 7.58 |
| CHEMBL5186450 | — | — | 1 | 7.58 |
| CHEMBL5182227 | — | — | 1 | 7.52 |
| CHEMBL5169393 | — | — | 1 | 7.47 |
| CHEMBL5171585 | — | — | 1 | 7.46 |
| CHEMBL5185049 | — | — | 1 | 7.42 |
| CHEMBL5169734 | — | — | 1 | 7.42 |
| CHEMBL5169946 | — | — | 1 | 7.40 |
| CHEMBL5179942 | — | — | 1 | 7.40 |
| CHEMBL5208819 | — | — | 1 | 7.38 |
| CHEMBL5202237 | — | — | 1 | 7.37 |
| CHEMBL5192191 | — | — | 1 | 7.25 |
| CHEMBL5198050 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098877 | MLi-2 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5187271 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5170359 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5194735 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5177346 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5206337 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5207998 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5201248 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5174552 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5176421 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5182067 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5196967 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5184816 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5200822 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5182980 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5179734 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5209350 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5172598 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5186450 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5182227 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5169393 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5171585 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5185049 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5169734 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5179942 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5169946 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5208819 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5202237 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5192191 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5198050 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5179131 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5207003 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5197876 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5188644 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5201629 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5200012 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL5186274 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL5194659 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL5189165 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL5206958 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5195812 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL5198808 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL5193770 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL5173860 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL5204222 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL5194653 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL5171090 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL5206767 | — | IC50 | = | 637.0 | nM | 6.20 |
| CHEMBL5196195 | — | IC50 | = | 646.0 | nM | 6.19 |
| CHEMBL5189805 | — | IC50 | = | 866.0 | nM | 6.06 |