Assay Detail
Toxicity
CHEMBL5157441
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Inhibition of OAT1 (unknown origin) expressed in HEK293 cells assessed as inhibition of 6-CFL uptake preincubated for 30 mins followed by incubation with 6-CFL and measured after 15 mins by fluorescence based analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 6 (CHEMBL1641347) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.59 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170470 | — | — | 1 | 4.89 |
| CHEMBL5190525 | — | — | 1 | 4.59 |
| CHEMBL5202967 | — | — | 1 | 4.49 |
| CHEMBL5178161 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170470 | — | IC50 | = | 12740.0 | nM | 4.89 |
| CHEMBL5190525 | — | IC50 | = | 25540.0 | nM | 4.59 |
| CHEMBL5202967 | — | IC50 | = | 32140.0 | nM | 4.49 |
| CHEMBL5178161 | — | IC50 | = | 41250.0 | nM | 4.38 |