Assay Detail
Functional
CHEMBL5157984
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at S1P1 receptor (unknown origin) expressed in PathHunter CHO-K1 EDG1 beta-arrestin cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by measuring chemiluminescence signal by microplate reader method
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PathHunter CHO-K1 EDG1 beta-arrestin |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 65 | 7.40 | 8.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170826 | — | — | 1 | 8.88 |
| CHEMBL114606 | — | — | 1 | 8.78 |
| CHEMBL5174924 | — | — | 1 | 8.73 |
| CHEMBL5177759 | — | — | 1 | 8.73 |
| CHEMBL5172303 | — | — | 1 | 8.43 |
| CHEMBL5179798 | — | — | 1 | 8.32 |
| CHEMBL5202775 | — | — | 1 | 8.31 |
| CHEMBL5183779 | — | — | 1 | 8.25 |
| CHEMBL5176185 | — | — | 1 | 8.19 |
| CHEMBL5176383 | — | — | 1 | 8.15 |
| CHEMBL5204567 | — | — | 1 | 8.08 |
| CHEMBL5198753 | — | — | 1 | 7.96 |
| CHEMBL5173606 | — | — | 1 | 7.74 |
| CHEMBL5202986 | — | — | 1 | 7.72 |
| CHEMBL5173103 | — | — | 1 | 7.69 |
| CHEMBL5197074 | — | — | 1 | 7.64 |
| CHEMBL5196884 | — | — | 1 | 7.59 |
| CHEMBL5182813 | — | — | 1 | 7.53 |
| CHEMBL5201690 | — | — | 1 | 7.46 |
| CHEMBL5178933 | — | — | 1 | 7.36 |
| CHEMBL5182920 | — | — | 1 | 7.28 |
| CHEMBL5192549 | — | — | 1 | 7.24 |
| CHEMBL5189040 | — | — | 1 | 7.19 |
| CHEMBL5177232 | — | — | 1 | 7.14 |
| CHEMBL5202350 | — | — | 1 | 7.13 |
| CHEMBL5169412 | — | — | 1 | 7.08 |
| CHEMBL5185995 | — | — | 1 | 7.06 |
| CHEMBL5186672 | — | — | 1 | 7.06 |
| CHEMBL5191622 | — | — | 1 | 7.02 |
| CHEMBL5199664 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170826 | — | EC50 | = | 1.31 | nM | 8.88 |
| CHEMBL114606 | — | EC50 | = | 1.67 | nM | 8.78 |
| CHEMBL5177759 | — | EC50 | = | 1.87 | nM | 8.73 |
| CHEMBL5174924 | — | EC50 | = | 1.84 | nM | 8.73 |
| CHEMBL5172303 | — | EC50 | = | 3.72 | nM | 8.43 |
| CHEMBL5179798 | — | EC50 | = | 4.74 | nM | 8.32 |
| CHEMBL5202775 | — | EC50 | = | 4.91 | nM | 8.31 |
| CHEMBL5183779 | — | EC50 | = | 5.57 | nM | 8.25 |
| CHEMBL5176185 | — | EC50 | = | 6.49 | nM | 8.19 |
| CHEMBL5176383 | — | EC50 | = | 7.03 | nM | 8.15 |
| CHEMBL5204567 | — | EC50 | = | 8.35 | nM | 8.08 |
| CHEMBL5198753 | — | EC50 | = | 11.1 | nM | 7.96 |
| CHEMBL5173606 | — | EC50 | = | 18.1 | nM | 7.74 |
| CHEMBL5202986 | — | EC50 | = | 19.1 | nM | 7.72 |
| CHEMBL5173103 | — | EC50 | = | 20.4 | nM | 7.69 |
| CHEMBL5197074 | — | EC50 | = | 23.1 | nM | 7.64 |
| CHEMBL5196884 | — | EC50 | = | 25.9 | nM | 7.59 |
| CHEMBL5182813 | — | EC50 | = | 29.6 | nM | 7.53 |
| CHEMBL5201690 | — | EC50 | = | 34.6 | nM | 7.46 |
| CHEMBL5178933 | — | EC50 | = | 43.3 | nM | 7.36 |
| CHEMBL5182920 | — | EC50 | = | 52.3 | nM | 7.28 |
| CHEMBL5192549 | — | EC50 | = | 57.5 | nM | 7.24 |
| CHEMBL5189040 | — | EC50 | = | 64.9 | nM | 7.19 |
| CHEMBL5177232 | — | EC50 | = | 72.6 | nM | 7.14 |
| CHEMBL5202350 | — | EC50 | = | 74.4 | nM | 7.13 |
| CHEMBL5169412 | — | EC50 | = | 83.4 | nM | 7.08 |
| CHEMBL5186672 | — | EC50 | = | 86.6 | nM | 7.06 |
| CHEMBL5185995 | — | EC50 | = | 87.3 | nM | 7.06 |
| CHEMBL5191622 | — | EC50 | = | 95.7 | nM | 7.02 |
| CHEMBL5199664 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5192922 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5183758 | — | EC50 | = | 131.0 | nM | 6.88 |
| CHEMBL5178428 | — | EC50 | = | 196.0 | nM | 6.71 |
| CHEMBL5186304 | — | EC50 | = | 219.0 | nM | 6.66 |
| CHEMBL5201117 | — | EC50 | = | 279.0 | nM | 6.55 |
| CHEMBL5203930 | — | EC50 | = | 346.0 | nM | 6.46 |
| CHEMBL5203643 | — | EC50 | = | 392.0 | nM | 6.41 |
| CHEMBL5208552 | — | EC50 | = | 402.0 | nM | 6.40 |
| CHEMBL5194896 | — | EC50 | = | 419.0 | nM | 6.38 |
| CHEMBL5208384 | — | EC50 | = | 542.0 | nM | 6.27 |
| CHEMBL5187844 | — | EC50 | = | 567.0 | nM | 6.25 |
| CHEMBL5181453 | — | EC50 | = | 867.0 | nM | 6.06 |
| CHEMBL5209429 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5190753 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5186460 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5173741 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5180613 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5180309 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5175958 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5181482 | — | EC50 | > | 1000.0 | nM | - |