Assay Detail
Functional
CHEMBL5157985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at S1P1 receptor (unknown origin) expressed in PathHunter HEK 293 EDG1 Total GPCR Internalization cells assessed as receptor internalization incubated for 90 mins by measuring chemiluminescence signal by microplate reader method
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PathHunter HEK 293 EDG1 Total GPCR Internalization |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 65 | 7.26 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114606 | — | — | 1 | 9.15 |
| CHEMBL5170826 | — | — | 1 | 9.08 |
| CHEMBL5172303 | — | — | 1 | 8.65 |
| CHEMBL5177759 | — | — | 1 | 8.59 |
| CHEMBL5174924 | — | — | 1 | 8.50 |
| CHEMBL5179798 | — | — | 1 | 8.39 |
| CHEMBL5183779 | — | — | 1 | 8.29 |
| CHEMBL5176185 | — | — | 1 | 7.96 |
| CHEMBL5176383 | — | — | 1 | 7.93 |
| CHEMBL5202775 | — | — | 1 | 7.86 |
| CHEMBL5198753 | — | — | 1 | 7.84 |
| CHEMBL5173103 | — | — | 1 | 7.78 |
| CHEMBL5178933 | — | — | 1 | 7.61 |
| CHEMBL5204567 | — | — | 1 | 7.60 |
| CHEMBL5196884 | — | — | 1 | 7.52 |
| CHEMBL5173606 | — | — | 1 | 7.46 |
| CHEMBL5182813 | — | — | 1 | 7.44 |
| CHEMBL5186672 | — | — | 1 | 7.42 |
| CHEMBL5197074 | — | — | 1 | 7.34 |
| CHEMBL5177232 | — | — | 1 | 7.20 |
| CHEMBL5202986 | — | — | 1 | 7.18 |
| CHEMBL5192922 | — | — | 1 | 7.09 |
| CHEMBL5189040 | — | — | 1 | 6.97 |
| CHEMBL5182920 | — | — | 1 | 6.96 |
| CHEMBL5178428 | — | — | 1 | 6.96 |
| CHEMBL5201690 | — | — | 1 | 6.95 |
| CHEMBL5199664 | — | — | 1 | 6.91 |
| CHEMBL5202350 | — | — | 1 | 6.84 |
| CHEMBL5192549 | — | — | 1 | 6.82 |
| CHEMBL5169412 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114606 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5170826 | — | EC50 | = | 0.84 | nM | 9.08 |
| CHEMBL5172303 | — | EC50 | = | 2.25 | nM | 8.65 |
| CHEMBL5177759 | — | EC50 | = | 2.59 | nM | 8.59 |
| CHEMBL5174924 | — | EC50 | = | 3.16 | nM | 8.50 |
| CHEMBL5179798 | — | EC50 | = | 4.06 | nM | 8.39 |
| CHEMBL5183779 | — | EC50 | = | 5.09 | nM | 8.29 |
| CHEMBL5176185 | — | EC50 | = | 11.1 | nM | 7.96 |
| CHEMBL5176383 | — | EC50 | = | 11.8 | nM | 7.93 |
| CHEMBL5202775 | — | EC50 | = | 13.8 | nM | 7.86 |
| CHEMBL5198753 | — | EC50 | = | 14.3 | nM | 7.84 |
| CHEMBL5173103 | — | EC50 | = | 16.8 | nM | 7.78 |
| CHEMBL5178933 | — | EC50 | = | 24.6 | nM | 7.61 |
| CHEMBL5204567 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5196884 | — | EC50 | = | 30.5 | nM | 7.52 |
| CHEMBL5173606 | — | EC50 | = | 34.6 | nM | 7.46 |
| CHEMBL5182813 | — | EC50 | = | 36.4 | nM | 7.44 |
| CHEMBL5186672 | — | EC50 | = | 38.5 | nM | 7.42 |
| CHEMBL5197074 | — | EC50 | = | 45.3 | nM | 7.34 |
| CHEMBL5177232 | — | EC50 | = | 63.2 | nM | 7.20 |
| CHEMBL5202986 | — | EC50 | = | 66.5 | nM | 7.18 |
| CHEMBL5192922 | — | EC50 | = | 80.6 | nM | 7.09 |
| CHEMBL5189040 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL5182920 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5178428 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5201690 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5199664 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL5202350 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL5192549 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5169412 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5183758 | — | EC50 | = | 209.0 | nM | 6.68 |
| CHEMBL5203930 | — | EC50 | = | 237.0 | nM | 6.62 |
| CHEMBL5201117 | — | EC50 | = | 283.0 | nM | 6.55 |
| CHEMBL5176091 | — | EC50 | = | 286.0 | nM | 6.54 |
| CHEMBL5186304 | — | EC50 | = | 313.0 | nM | 6.50 |
| CHEMBL5191622 | — | EC50 | = | 346.0 | nM | 6.46 |
| CHEMBL5194896 | — | EC50 | = | 378.0 | nM | 6.42 |
| CHEMBL5185995 | — | EC50 | = | 385.0 | nM | 6.42 |
| CHEMBL5187844 | — | EC50 | = | 414.0 | nM | 6.38 |
| CHEMBL5203643 | — | EC50 | = | 594.0 | nM | 6.23 |
| CHEMBL5172318 | — | EC50 | = | 813.0 | nM | 6.09 |
| CHEMBL5181453 | — | EC50 | = | 876.0 | nM | 6.06 |
| CHEMBL5208384 | — | EC50 | = | 973.0 | nM | 6.01 |
| CHEMBL5180613 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5180579 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5180309 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5173741 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5186460 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5191394 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5209429 | — | EC50 | > | 1000.0 | nM | - |