Assay Detail
Binding
CHEMBL5158467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cathepsin E (unknown origin) using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mins by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cathepsin D inhibitors based on tasiamide B derivatives with cell membrane permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.58 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296588 | PEPSTATIN | 2.0 | 1 | 9.35 |
| CHEMBL2181022 | — | — | 1 | 9.14 |
| CHEMBL5184529 | — | — | 1 | 7.92 |
| CHEMBL2181015 | — | — | 1 | 7.18 |
| CHEMBL5184180 | — | — | 1 | 7.00 |
| CHEMBL5184970 | — | — | 1 | 6.98 |
| CHEMBL5192597 | — | — | 1 | 6.98 |
| CHEMBL5179569 | — | — | 1 | 6.92 |
| CHEMBL5188873 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296588 | PEPSTATIN | IC50 | = | 0.446 | nM | 9.35 |
| CHEMBL2181022 | — | IC50 | = | 0.724 | nM | 9.14 |
| CHEMBL5184529 | — | IC50 | = | 12.04 | nM | 7.92 |
| CHEMBL2181015 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5184180 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5184970 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL5192597 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5179569 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5188873 | — | IC50 | = | 187.0 | nM | 6.73 |