Assay Detail
Binding
CHEMBL5158768
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Inhibition of bacterial NDM-1 using CDC-1 as substrate incubated for 30 mins
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Stereochemically altered cephalosporins as potent inhibitors of New Delhi metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.11 | 6.89 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193687 | — | — | 1 | 6.89 |
| CHEMBL5197006 | — | — | 1 | 6.72 |
| CHEMBL5188069 | — | — | 1 | 6.70 |
| CHEMBL5185416 | — | — | 1 | 6.66 |
| CHEMBL5191723 | — | — | 1 | 6.60 |
| CHEMBL5194932 | — | — | 1 | 6.51 |
| CHEMBL5175271 | — | — | 1 | 6.34 |
| CHEMBL5182259 | — | — | 1 | 6.30 |
| CHEMBL858 | EDETIC ACID | 3.0 | 1 | 6.27 |
| CHEMBL5178017 | — | — | 1 | 6.26 |
| CHEMBL5173583 | — | — | 1 | 6.21 |
| CHEMBL5172396 | — | — | 1 | 6.20 |
| CHEMBL5185452 | — | — | 1 | 6.20 |
| CHEMBL5203817 | — | — | 1 | 6.12 |
| CHEMBL5189881 | — | — | 1 | 6.00 |
| CHEMBL5176475 | — | — | 1 | 5.92 |
| CHEMBL5198686 | — | — | 1 | 5.85 |
| CHEMBL5200653 | — | — | 1 | 5.80 |
| CHEMBL5182042 | — | — | 1 | 5.70 |
| CHEMBL5183074 | — | — | 1 | 5.13 |
| CHEMBL5187720 | — | — | 1 | 5.03 |
| CHEMBL5198046 | — | — | 1 | 5.02 |
| CHEMBL5177073 | — | — | 1 | - |
| CHEMBL5202976 | — | — | 1 | - |
| CHEMBL5190620 | — | — | 1 | - |
| CHEMBL5179433 | — | — | 1 | - |
| CHEMBL5197345 | — | — | 1 | - |
| CHEMBL617 | CEPHALOTHIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193687 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5197006 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5188069 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5185416 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5191723 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5194932 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5175271 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5182259 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL858 | EDETIC ACID | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5178017 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5173583 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5172396 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5185452 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5203817 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5189881 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5176475 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5198686 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5200653 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5182042 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5183074 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5187720 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5198046 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL5177073 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5202976 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5190620 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5179433 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5197345 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL617 | CEPHALOTHIN | Inhibition | - | % | - |