Assay Detail
Binding
CHEMBL5159134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length human AAK1 expressed in HEK293F incubated for 3 hrs by Western blot analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293F |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.38 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5202351 | — | — | 1 | 7.72 |
| CHEMBL5194899 | — | — | 1 | 7.50 |
| CHEMBL5201888 | — | — | 1 | 7.47 |
| CHEMBL5208293 | — | — | 1 | 7.31 |
| CHEMBL4872886 | — | — | 1 | 7.29 |
| CHEMBL5182431 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5202351 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5194899 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5201888 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5208293 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4872886 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5182431 | — | IC50 | = | 108.0 | nM | 6.97 |