Assay Detail
Functional
CHEMBL5159664
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Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.86 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3716365 | GLPG-1205 | 2.0 | 1 | 7.24 |
| CHEMBL5179395 | — | — | 1 | 6.97 |
| CHEMBL5194984 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3716365 | GLPG-1205 | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5179395 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5194984 | — | IC50 | = | 413.0 | nM | 6.38 |