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Assay Detail

CHEMBL5159715

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate incubated for 1 hr by luciferin-based luminescence assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BTI
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.
Li C, Su M, Zhu W, Kan W, Ge T, Xu G, Wang S, Sheng L, Gao F, Ye Y, Wang J, Zhou Y, Li J, Liu H.
J Med Chem (2022) 65 : 4335 -4349
PubMed 35200034 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 4.57 5.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5191876 1 5.50
CHEMBL257990 (+)-TRANYLCYPROMINE 1 5.37
CHEMBL5197243 1 5.04
CHEMBL5201504 1 4.48
CHEMBL5181753 1 4.39
CHEMBL5208082 1 4.15
CHEMBL5191047 1 4.09
CHEMBL5196564 1 4.07
CHEMBL5205837 1 4.05
CHEMBL5171190 1 -
CHEMBL5177857 1 -
CHEMBL5170011 1 -
CHEMBL5191605 1 -
CHEMBL5170567 1 -
CHEMBL5206450 1 -
CHEMBL5175125 1 -
CHEMBL5172252 1 -
CHEMBL5183291 1 -
CHEMBL5174599 1 -
CHEMBL5194745 1 -
CHEMBL5174650 1 -
CHEMBL5196436 1 -
CHEMBL5184995 1 -
CHEMBL5204790 1 -
CHEMBL3764353 1 -
CHEMBL3786182 GSK2879552 1.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5191876 IC50 = 3140.0 nM 5.50
CHEMBL257990 (+)-TRANYLCYPROMINE IC50 = 4300.0 nM 5.37
CHEMBL5197243 IC50 = 9220.0 nM 5.04
CHEMBL5201504 IC50 = 32880.0 nM 4.48
CHEMBL5181753 IC50 = 40870.0 nM 4.39
CHEMBL5208082 IC50 = 70680.0 nM 4.15
CHEMBL5191047 IC50 = 81980.0 nM 4.09
CHEMBL5196564 IC50 = 86160.0 nM 4.07
CHEMBL5205837 IC50 = 89380.0 nM 4.05
CHEMBL5171190 IC50 > 100000.0 nM -
CHEMBL5177857 IC50 > 100000.0 nM -
CHEMBL5170011 IC50 > 100000.0 nM -
CHEMBL5191605 IC50 > 100000.0 nM -
CHEMBL5170567 IC50 > 100000.0 nM -
CHEMBL5206450 IC50 > 100000.0 nM -
CHEMBL5175125 IC50 > 100000.0 nM -
CHEMBL5172252 IC50 > 100000.0 nM -
CHEMBL5183291 IC50 > 100000.0 nM -
CHEMBL5174599 IC50 > 100000.0 nM -
CHEMBL5194745 IC50 > 100000.0 nM -
CHEMBL5174650 IC50 > 100000.0 nM -
CHEMBL5196436 IC50 > 100000.0 nM -
CHEMBL5184995 IC50 > 100000.0 nM -
CHEMBL5204790 IC50 > 100000.0 nM -
CHEMBL3764353 IC50 > 100000.0 nM -
CHEMBL3786182 GSK2879552 IC50 > 100000.0 nM -