Compound Detail
CHEMBL5174599
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5174599 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DFOFKLSGYBTRDH-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
349.5
MW (Da)
1.45
ALogP
4
HBA
2
HBD
61.4
PSA (Ų)
0.84
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MV4-11 CHEMBL613835 | IC50 | 5.62 | 5.62 | 2390.0 | 1 |
| Lysine-specific histone demethylase 2 CHEMBL1938208 | IC50 | 4.71 | 4.71 | 19510.0 | 1 |
| Lysine-specific histone demethylase 1A CHEMBL6136 | IC50 | 4.37 | 4.37 | 42530.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MV4-11 | IC50 | = | 2390.0 | nM | 5.62 | Antiproliferative activity against human MV4-11 cells assessed as inhibition of ... | 35200034 |
| Lysine-specific histone demethylase 2 | IC50 | = | 19510.0 | nM | 4.71 | Inhibition of recombinant human full length LSD2 using biotinylated H3K4Me2 pept... | 35200034 |
| Lysine-specific histone demethylase 1A | IC50 | = | 42530.0 | nM | 4.37 | Inhibition of N-terminal His/GST-tagged human LSD1 (172 to 852 residues) express... | 35200034 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35200034 | 10.1021/acs.jmedchem.1c02156 | Unchecked | 2 |
| 35200034 | 10.1021/acs.jmedchem.1c02156 | Lysine-specific histone demethylase 1A | 1 |
| 35200034 | 10.1021/acs.jmedchem.1c02156 | Lysine-specific histone demethylase 2 | 1 |
| 35200034 | 10.1021/acs.jmedchem.1c02156 | Amine oxidase [flavin-containing] A | 1 |
| 35200034 | 10.1021/acs.jmedchem.1c02156 | Amine oxidase [flavin-containing] B | 1 |
| 35200034 | 10.1021/acs.jmedchem.1c02156 | MV4-11 | 1 |
Data from ChEMBL 36 via Core Engine