Assay Detail
Binding
CHEMBL5159713
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length LSD2 using biotinylated H3K4Me2 peptide as substrate by TR-FRET assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 2 (CHEMBL1938208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.45 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206450 | — | — | 1 | 6.22 |
| CHEMBL5191047 | — | — | 1 | 6.12 |
| CHEMBL5205837 | — | — | 1 | 6.10 |
| CHEMBL5181753 | — | — | 1 | 6.00 |
| CHEMBL5196564 | — | — | 1 | 5.99 |
| CHEMBL5177857 | — | — | 1 | 5.83 |
| CHEMBL5194745 | — | — | 1 | 5.65 |
| CHEMBL5184995 | — | — | 1 | 5.59 |
| CHEMBL5170567 | — | — | 1 | 5.49 |
| CHEMBL5204790 | — | — | 1 | 5.40 |
| CHEMBL5172252 | — | — | 1 | 5.40 |
| CHEMBL5174650 | — | — | 1 | 5.40 |
| CHEMBL5191876 | — | — | 1 | 5.38 |
| CHEMBL5201504 | — | — | 1 | 5.35 |
| CHEMBL5170011 | — | — | 1 | 5.30 |
| CHEMBL5208082 | — | — | 1 | 5.27 |
| CHEMBL5175125 | — | — | 1 | 5.19 |
| CHEMBL5197243 | — | — | 1 | 5.12 |
| CHEMBL5171190 | — | — | 1 | 5.05 |
| CHEMBL5191605 | — | — | 1 | 5.04 |
| CHEMBL5183291 | — | — | 1 | 5.01 |
| CHEMBL5196436 | — | — | 1 | 4.81 |
| CHEMBL5174599 | — | — | 1 | 4.71 |
| CHEMBL3786182 | GSK2879552 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206450 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5191047 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5205837 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5181753 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5196564 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5177857 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL5194745 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL5184995 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL5170567 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL5204790 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5172252 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5174650 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL5191876 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL5201504 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL5170011 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5208082 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL5175125 | — | IC50 | = | 6470.0 | nM | 5.19 |
| CHEMBL5197243 | — | IC50 | = | 7510.0 | nM | 5.12 |
| CHEMBL5171190 | — | IC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL5191605 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL5183291 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5196436 | — | IC50 | = | 15560.0 | nM | 4.81 |
| CHEMBL5174599 | — | IC50 | = | 19510.0 | nM | 4.71 |
| CHEMBL3786182 | GSK2879552 | IC50 | > | 100000.0 | nM | - |