Assay Detail
Functional
CHEMBL5160032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite growth by SYBR Green-I dye based fluorescence analysis
68
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 68 | 7.26 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5200418 | — | — | 1 | 8.30 |
| CHEMBL5173264 | INE-963 | 2.0 | 1 | 8.22 |
| CHEMBL5201780 | — | — | 1 | 8.05 |
| CHEMBL5173325 | — | — | 1 | 8.05 |
| CHEMBL5174770 | — | — | 1 | 7.96 |
| CHEMBL5196893 | — | — | 1 | 7.89 |
| CHEMBL5207627 | — | — | 1 | 7.85 |
| CHEMBL5173722 | — | — | 1 | 7.85 |
| CHEMBL5199435 | — | — | 1 | 7.77 |
| CHEMBL5189523 | — | — | 1 | 7.77 |
| CHEMBL5174065 | — | — | 1 | 7.77 |
| CHEMBL5181699 | — | — | 1 | 7.77 |
| CHEMBL5185965 | — | — | 2 | 7.70 |
| CHEMBL5192443 | — | — | 1 | 7.70 |
| CHEMBL5198037 | — | — | 2 | 7.70 |
| CHEMBL5181112 | — | — | 1 | 7.68 |
| CHEMBL5201904 | — | — | 1 | 7.68 |
| CHEMBL5189070 | — | — | 1 | 7.66 |
| CHEMBL5200247 | — | — | 1 | 7.66 |
| CHEMBL5178777 | — | — | 2 | 7.62 |
| CHEMBL5179988 | — | — | 1 | 7.60 |
| CHEMBL5190339 | — | — | 2 | 7.58 |
| CHEMBL5204715 | — | — | 1 | 7.55 |
| CHEMBL5187610 | — | — | 1 | 7.55 |
| CHEMBL5169763 | — | — | 2 | 7.54 |
| CHEMBL5187946 | — | — | 2 | 7.54 |
| CHEMBL5197907 | — | — | 2 | 7.51 |
| CHEMBL5175200 | — | — | 1 | 7.48 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.47 |
| CHEMBL5193817 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5200418 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5173264 | INE-963 | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5201780 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5173325 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5174770 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5196893 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5173722 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5207627 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5174065 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5189523 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5199435 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5181699 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5185965 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5198037 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5185965 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5192443 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5198037 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5181112 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5201904 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5200247 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5189070 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5178777 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5179988 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5190339 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5178777 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5204715 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5190339 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5187610 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5169763 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5169763 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5187946 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5197907 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5175200 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL172 | (S,R)-MEFLOQUINE | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5197907 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5193817 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5187817 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5206310 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5178067 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5187946 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5195201 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5172261 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5188137 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5206260 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5187715 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5178067 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5187715 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5189235 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5191906 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5197359 | — | EC50 | = | 82.0 | nM | 7.09 |