Compound Detail
CHEMBL5192443
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5192443 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IGGCHUXCYBHUAQ-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
317.5
MW (Da)
3.07
ALogP
6
HBA
1
HBD
59.5
PSA (Ų)
0.92
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.7
IC50 1 meas. best 7.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | EC50 | 7.7 | 7.7 | 20.0 | 1 |
| Serine/threonine-protein kinase haspin CHEMBL1075163 | IC50 | 7.35 | 7.35 | 45.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | EC50 | = | 20.0 | nM | 7.7 | Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythr... | 35229610 |
| Serine/threonine-protein kinase haspin | IC50 | = | 45.0 | nM | 7.35 | Inhibition of human Haspin kinase domain using histone H3 biotin peptide as subs... | 35229610 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35229610 | 10.1021/acs.jmedchem.1c01995 | Plasmodium falciparum | 1 |
| 35229610 | 10.1021/acs.jmedchem.1c01995 | Serine/threonine-protein kinase haspin | 1 |
Data from ChEMBL 36 via Core Engine