Assay Detail
Functional
CHEMBL5161053
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1975 cells harbouring EGFR T790M/L858R mutant by sulforhodamine B assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.91 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182791 | — | — | 1 | 5.46 |
| CHEMBL5208907 | — | — | 1 | 5.23 |
| CHEMBL5198424 | — | — | 1 | 5.01 |
| CHEMBL5194966 | — | — | 1 | 4.96 |
| CHEMBL5174372 | — | — | 1 | 4.86 |
| CHEMBL5193902 | — | — | 1 | 4.82 |
| CHEMBL5169328 | — | — | 1 | 4.77 |
| CHEMBL5200760 | — | — | 1 | 4.74 |
| CHEMBL5176588 | — | — | 1 | 4.65 |
| CHEMBL5180251 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182791 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5208907 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5198424 | — | IC50 | = | 9820.0 | nM | 5.01 |
| CHEMBL5194966 | — | IC50 | = | 10850.0 | nM | 4.96 |
| CHEMBL5174372 | — | IC50 | = | 13890.0 | nM | 4.86 |
| CHEMBL5193902 | — | IC50 | = | 15020.0 | nM | 4.82 |
| CHEMBL5169328 | — | IC50 | = | 16880.0 | nM | 4.77 |
| CHEMBL5200760 | — | IC50 | = | 18130.0 | nM | 4.74 |
| CHEMBL5176588 | — | IC50 | = | 22590.0 | nM | 4.65 |
| CHEMBL5180251 | — | IC50 | = | 27220.0 | nM | 4.57 |