Assay Detail
Binding
CHEMBL5161244
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Inhibition of MNK1 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 1 (CHEMBL4718) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.39 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205578 | — | — | 1 | 6.92 |
| CHEMBL5170576 | — | — | 1 | 6.72 |
| CHEMBL4092824 | — | — | 1 | 6.60 |
| CHEMBL5199698 | — | — | 1 | 6.58 |
| CHEMBL5194667 | — | — | 1 | 6.31 |
| CHEMBL5195653 | — | — | 1 | 5.89 |
| CHEMBL5204513 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205578 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5170576 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4092824 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5199698 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5194667 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5195653 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5204513 | — | IC50 | = | 1900.0 | nM | 5.72 |