Assay Detail
Functional
CHEMBL5161318
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 5 days by SRB assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.78 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3828009 | LY-2874455 | 1.0 | 1 | 8.30 |
| CHEMBL5200423 | — | — | 1 | 8.15 |
| CHEMBL5204315 | — | — | 1 | 8.00 |
| CHEMBL5193422 | — | — | 1 | 7.85 |
| CHEMBL5169893 | — | — | 1 | 7.75 |
| CHEMBL5182986 | — | — | 1 | 7.48 |
| CHEMBL5194425 | — | — | 1 | 7.47 |
| CHEMBL5198859 | — | — | 1 | 7.21 |
| CHEMBL5198766 | — | — | 1 | 7.19 |
| CHEMBL5185977 | — | — | 1 | 6.96 |
| CHEMBL5197977 | — | — | 1 | 6.92 |
| CHEMBL5205272 | — | — | 1 | 6.72 |
| CHEMBL5199623 | — | — | 1 | 6.68 |
| CHEMBL5193330 | — | — | 1 | 6.24 |
| CHEMBL5181936 | — | — | 1 | 6.21 |
| CHEMBL5194949 | — | — | 1 | 6.12 |
| CHEMBL5172905 | — | — | 1 | 5.29 |
| CHEMBL5169754 | — | — | 1 | 5.12 |
| CHEMBL5182404 | — | — | 1 | 5.12 |
| CHEMBL5200516 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3828009 | LY-2874455 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5200423 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5204315 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5193422 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5169893 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5182986 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5194425 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5198859 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5198766 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5185977 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5197977 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5205272 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5199623 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5193330 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5181936 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5194949 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5172905 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL5169754 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL5182404 | — | IC50 | = | 7590.0 | nM | 5.12 |
| CHEMBL5200516 | — | IC50 | = | 15200.0 | nM | 4.82 |