Assay Detail
Functional
CHEMBL5161328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 5 days by SRB assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.16 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5198859 | — | — | 1 | 7.32 |
| CHEMBL5194425 | — | — | 1 | 7.14 |
| CHEMBL5169893 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5198859 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5194425 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5169893 | — | IC50 | = | 96.0 | nM | 7.02 |