Assay Detail
Binding
CHEMBL5161346
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Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 240 sec by Ellman's method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.78 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2007996 | — | — | 1 | 9.13 |
| CHEMBL5207628 | — | — | 1 | 8.71 |
| CHEMBL5200047 | — | — | 1 | 8.57 |
| CHEMBL5178885 | — | — | 1 | 7.89 |
| CHEMBL5204900 | — | — | 1 | 7.84 |
| CHEMBL292314 | — | — | 1 | 7.84 |
| CHEMBL2021616 | — | — | 1 | 6.49 |
| CHEMBL5188116 | — | — | 1 | 5.78 |
| CHEMBL1668934 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2007996 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL5207628 | — | IC50 | = | 1.94 | nM | 8.71 |
| CHEMBL5200047 | — | IC50 | = | 2.71 | nM | 8.57 |
| CHEMBL5178885 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL5204900 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL292314 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL2021616 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL5188116 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL1668934 | — | IC50 | = | 115000.0 | nM | - |