Assay Detail
Binding
CHEMBL5161380
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Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of a Pyrimidinone Series for Selective Inhibition of Ca<sup>2+</sup>/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.97 | 6.05 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188949 | — | — | 1 | 6.05 |
| CHEMBL5187824 | — | — | 1 | 5.89 |
| CHEMBL5202029 | — | — | 1 | - |
| CHEMBL5182403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188949 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL5187824 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL5202029 | — | Inhibition | = | 49.0 | % | - |
| CHEMBL5182403 | — | Inhibition | = | 32.0 | % | - |