Assay Detail
Functional
CHEMBL5161385
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Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of a Pyrimidinone Series for Selective Inhibition of Ca<sup>2+</sup>/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.38 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5187824 | — | — | 1 | 6.38 |
| CHEMBL5188949 | — | — | 1 | 6.38 |
| CHEMBL5202029 | — | — | 1 | 6.38 |
| CHEMBL5182403 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5187824 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5188949 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5202029 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5182403 | — | IC50 | = | 420.0 | nM | 6.38 |