Assay Detail
Functional
CHEMBL5161722
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Antiproliferative activity against human HCT-116 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.17 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183361 | — | — | 1 | 6.80 |
| CHEMBL5181060 | — | — | 1 | 6.34 |
| CHEMBL5181982 | — | — | 1 | 6.14 |
| CHEMBL5209239 | — | — | 1 | 6.10 |
| CHEMBL5201806 | — | — | 1 | 6.06 |
| CHEMBL5175132 | — | — | 1 | 5.96 |
| CHEMBL5188784 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183361 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5181060 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5181982 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5209239 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5201806 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5175132 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL5188784 | — | IC50 | = | 1700.0 | nM | 5.77 |