Assay Detail
Binding
CHEMBL5161730
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Inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) assessed as residual activity
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphotyrosine-protein phosphatase PTPB (CHEMBL4540) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Virtual screening and crystallographic studies reveal an unexpected γ-lactone derivative active against MptpB as a potential antitubercular agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.39 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4214022 | — | — | 1 | 4.59 |
| CHEMBL5179645 | — | — | 2 | 4.51 |
| CHEMBL5186703 | — | — | 1 | 4.32 |
| CHEMBL5197346 | — | — | 1 | - |
| CHEMBL5180748 | — | — | 1 | - |
| CHEMBL5186434 | — | — | 1 | - |
| CHEMBL5171668 | — | — | 1 | - |
| CHEMBL5199222 | — | — | 1 | - |
| CHEMBL5193446 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4214022 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL5179645 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL5186703 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL5179645 | — | IC50 | = | 72200.0 | nM | 4.14 |
| CHEMBL5197346 | — | IC50 | - | — | - | |
| CHEMBL5180748 | — | IC50 | - | — | - | |
| CHEMBL5186434 | — | IC50 | - | — | - | |
| CHEMBL5171668 | — | IC50 | - | — | - | |
| CHEMBL5199222 | — | IC50 | - | — | - | |
| CHEMBL5193446 | — | IC50 | - | — | - |